Jon Wilkins, drummer for the Freakin' Hott (and sometimes New Times freelancer), answers the question:
What's the best/worst pickup line you've used that actually worked?
"Ever been smacked in the face with a balloon full of warm oatmeal? That's what it's like being with me, baby."
Witnesses corroborate the fact that this line has worked more than once. The conclusion? Girls will go for anything.