After acclaimed actor Lawrence Talbot (Del Toro) receives a letter from his brothers fiancée (Emily Blunt) informing him of his siblings disappearance, he hightails it from the New York stage to the sprawling home of his estranged family, only to be greeted with the news that his brothers badly mutilated body has been recovered. A bonehead move that the script passes off as heroism (lots of those) soon results in Talbot being bitten by the creature who killed his brother. Blood, gore and a laughably bad insane asylum sequence ensue.
Some father-son conflict (papa Talbot is played by Anthony Hopkins, alternately hammy and sleepwalking through the part) juices the film a bit, but not enough to save it.